Transition metal Kinamycin model as a DNA photocleaver for hypoxic environments: bis(9-diazo-4,5-diazafluorene)copper(II) nitrate†

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Hilary J. Eppley, Susan M. Lato, Jeffrey M. Zaleski and Andrew D. Ellington


Abstract

Bis(9-diazo-4,5-diazafluorene)copper(II) nitrate is an effective DNA photocleaving agent under anaerobic conditions using visible light and represents a potential model for the action of Kinamycin antitumor antibiotics.


References

  1. S. Mithani, G. Weeratunga, N. J. Taylor and G. I. Dmitrienko, J. Am. Chem. Soc., 1994, 116, 2209 CrossRef CAS.
  2. S. J. Gould, N. Tamayo, C. R. Melville and M. C. Cone, J. Am. Chem. Soc., 1994, 116, 2207 CrossRef CAS.
  3. M. Regitz and G. Maas, Diazo Compounds: Properties and Synthesis, Academic Press, Orlando, 1986 Search PubMed.
  4. B. G. Maiya, C. V. Ramana, S. Arounaguiri and M. Nagarajan, Bioorg. Med. Chem. Lett., 1997, 7, 2141 CrossRef CAS.
  5. K. Nakantani, S. Maekawa, K. Tanabe and I. Saito, J. Am. Chem. Soc., 1995, 117, 10635 CrossRef CAS.
  6. V. D. Parker and D. Bethell, J. Am. Chem. Soc., 1987, 109, 5066 CrossRef CAS.
  7. D. P. Arya and D. J. Jabaratnan, J. Org. Chem., 1995, 60, 3268 CrossRef CAS.
  8. D. Bethell and V. D. Parker, J. Am. Chem. Soc., 1986, 108, 7194 CrossRef CAS.
  9. N. Koga, Y. Ishimaru and H. Iwamura, Angew. Chem., Int. Ed. Engl., 1996, 35, 755 CrossRef CAS.
  10. H. J. Eppley, J. C. Huffman and J. M. Zaleski, in preparation.
  11. S. J. Hawthorne, M. Pagano, P. Harriott, D. W. Halton and B. Walker, Anal. Biochem., 1998, 261, 131 CrossRef CAS.
  12. A. A. Abdel-Wahab, M. T. Ismail, O. S. Mohamed, H. Durr and Y. Ma, Liebigs Ann./Recl., 1997, 1611 Search PubMed.
  13. P. N. W. Baxter, J. A. Conner, J. D. Wallis, D. C. Povey and A. K. Powell, J. Chem. Soc., Perkin Trans. 1, 1992, 13, 1601 RSC.
  14. J. Fossey, D. Lefort and J. Sorba, Free Radicals in Organic Chemistry, Wiley, New York, 1995 Search PubMed.
  15. J. S. Wieczorek, B. Boduszek and R. Gancarz, J. Prakt. Chem., 1984, 326, 349 CAS.
  16. D. G. Stoub and J. L. Goodman, J. Am. Chem. Soc., 1997, 119, 11 110 CrossRef CAS.
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