Diastereoselective Baylis–Hillman reaction of 4-oxoazetidine-2-carbaldehydes: rapid, stereocontrolled and divergent radical synthesis of highly functionalised β-lactams fused to medium rings

Abstract

Baylis–Hillman adducts derived from enantiopure 1-alkenyl- or alkynyl-4-oxoazetidine-2-carbaldehydes are used for the stereoselective and divergent preparation of highly functionalised β-lactams fused to medium rings through novel, chemocontrolled tandem radical addition–cyclization sequences.

References

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