DOI: 10.1039/A904362D
(Paper)
Reference Section for: Chem. Commun., 1999, 1435-1436
Specific crosslinking of cell adhesive molecules by heterobifunctional glycopeptide synthesised on the basis of chemoenzymatic strategy
(Note: The full text of this document is currently only available in the PDF Version )
Shin-Ichiro Nishimura, Masao Matsuda, Hidemitsu Kitamura and Takashi Nishimura
Abstract
Heterobifunctional glycopeptide 1 composed of Neu5Acα-(2→3)Galβ(1→4)[Fucα(1→3)]GlcNAc (sialyl Lewisx) and Lys-Gly-Arg-Gly-Asp-Ser (KGRGDS) having specific activity to bind concurrently with two different types of cell adhesive molecules such as selectins and integrins was synthesised on the basis of a combined chemical and enzymatic strategy.
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