Highly regio- and enantio-selective rhodium-catalysed asymmetric hydroformylation without organic solvents

Abstract

High enantioselectivity and unprecedented high regioselectivity without the need for hazardous organic solvents are achieved in rhodium-catalysed asymmetric hydroformylation with the perfluoroalkyl-substituted ligand (R,S)-3-H²F⁶-BINAPHOS, whereby the substitution pattern of the ligand is crucial for its successful use in compressed carbon dioxide and for the increased regioselectivity.

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