One-pot synthesis of γ-lactams in a reaction cascade from α,β-unsaturated imines, CO and ethylene catalysed by Ru₃(CO)₁₂†

Abstract

The formation of 1,3-dihydropyrrol-2-one derivatives in moderate to excellent yields may be achieved by sequential insertion of CO and ethylene into C–H bonds of 1-azadienes catalysed by Ru₃(CO)₁₂; thus two new C–C bonds and a new center of asymmetry at C3 are produced via an intramolecular aldol condensation-like cyclization.

References

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