Highly active supported palladium catalyst for the regioselective synthesis of 2-arylpropionic acids by carbonylation

Abstract

A catalyst system consisting of supported palladium in the presence of phosphine ligands, TsOH and LiCl catalyses the carbonylation of 1-arylethanols to 2-arylpropionic acids with significantly improved activity and regioselectivity; the catalyst can be recycled with no loss in activity and selecivity.

References

1. R. A. Sheldon, Chem. Ind., 1992, 903; C. B. Dartt and M. E. Davis, Ind. Eng. Chem. Res., 1994, 33, 2887.
2. J. N. Armor, Appl. Catal., 1991, 78, 141.
3. V. Elango, D. G. Kenneth, M. M. Alan, M. N. Graham, Z. G. Edward and S. B. Lee, EP 400 892, 1990.
4. A. Seayad, A. A. Kelkar and R. V. Chaudhari, Stud. Surf. Sci. Catal., 1998, 113, 883.
5. E. J. Jang, K. H. Lee, J. S. Lee and Y. G. Kim, J. Mol. Catal. A: Chem., 1999, 138, 25.
6. G. Papadogianakis, L. Maat and R. A. Sheldon, J. Chem. Technol. Biotechnol., 1997, 70, 83; G. Papadogianakis, G. Verspui, L. Maat and R. A. Sheldon, Catal. Lett., 1997, 47, 43.
7. B. E. Ali, G. Vasapollo and H. Alper, J. Org. Chem., 1993, 58, 4739.