Exploring a chemical encoding strategy for combinatorial synthesis using Friedel–Crafts alkylation

Abstract

The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel–Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b–i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.

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