A novel stationary phase for chiral chromatography: poly-L-leucine supported on porous graphitic carbon and its application to the separation of the enantiomers of chiral epoxides

Abstract

A novel chiral stationary phase consisting of poly-L-leucine supported on porous graphitic carbon has been shown to be effective in the separation of the enantiomers of epoxides 1-5 by chiral high performance liquid chromatography.

References

1. A Practical Approach to Chiral Separations by Liquid Chromatography, ed. G. Subramanian, VCH, New York, 1994.
2. Y. Okamoto, M. Kawashima and K. Hatada, J. Am. Chem. Soc., 1984, 106, 5357.
3. T. D. Booth, W. J. Lough, M. Saeed, T. A. G. Nocter and I. W. Wainer, Chirality, 1997, 9, 173.
4. S. Banfi, S. Colonna, H. Molinari, S. Julia and J. Guixer, Tetrahedron, 1984, 40, 5207.
5. W. Kroutil, M. E. Lasterra-Sanhez, S. J. Maddrell, P. Mayon, P. Morgan, S. M. Roberts, S. R. Thornton, C. J. Todd and M. Tuter, J. Chem. Soc., Perkin Trans. 1, 1996, 2837.
6. S. Ebrahim and M. Wills, Tetrahedron: Asymmetry, 1997, 8, 3163.
7. L. Pu, Tetrahedron: Asymmetry, 1998, 9, 1457.
8. S. Colonna, H. Molinari, S. Banfi, S. Julia, J. Masana and A. Alvarez, Tetrahedron, 1983, 39, 1635.
9. P. A. Bentley, W. Kroutil, J. A. Littlechild and S. M. Roberts, Chirality, 1997, 9, 198.
10. C. Hirayama, H. Ihara and K. Tanaka, J. Chromatogr., 1988, 450, 271.