A novel stationary phase for chiral chromatography: poly-L-leucine supported on porous graphitic carbon and its application to the separation of the enantiomers of chiral epoxides

(Note: The full text of this document is currently only available in the PDF Version )

Elizabeth J. Kelly, David M. Haddleton, David H. G. Crout, Paul Ross and James Dutton


Abstract

A novel chiral stationary phase consisting of poly-L-leucine supported on porous graphitic carbon has been shown to be effective in the separation of the enantiomers of epoxides 1-5 by chiral high performance liquid chromatography.


References

  1. A Practical Approach to Chiral Separations by Liquid Chromatography, ed. G. Subramanian, VCH, New York, 1994 Search PubMed.
  2. Y. Okamoto, M. Kawashima and K. Hatada, J. Am. Chem. Soc., 1984, 106, 5357 CrossRef CAS.
  3. T. D. Booth, W. J. Lough, M. Saeed, T. A. G. Nocter and I. W. Wainer, Chirality, 1997, 9, 173 CrossRef CAS.
  4. S. Banfi, S. Colonna, H. Molinari, S. Julia and J. Guixer, Tetrahedron, 1984, 40, 5207 CrossRef CAS.
  5. W. Kroutil, M. E. Lasterra-Sanhez, S. J. Maddrell, P. Mayon, P. Morgan, S. M. Roberts, S. R. Thornton, C. J. Todd and M. Tuter, J. Chem. Soc., Perkin Trans. 1, 1996, 2837 RSC.
  6. S. Ebrahim and M. Wills, Tetrahedron: Asymmetry, 1997, 8, 3163 CrossRef CAS.
  7. L. Pu, Tetrahedron: Asymmetry, 1998, 9, 1457 CrossRef CAS.
  8. S. Colonna, H. Molinari, S. Banfi, S. Julia, J. Masana and A. Alvarez, Tetrahedron, 1983, 39, 1635 CrossRef CAS.
  9. P. A. Bentley, W. Kroutil, J. A. Littlechild and S. M. Roberts, Chirality, 1997, 9, 198 CrossRef CAS.
  10. C. Hirayama, H. Ihara and K. Tanaka, J. Chromatogr., 1988, 450, 271 CrossRef CAS.
Click here to see how this site uses Cookies. View our privacy policy here.