Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate

Abstract

The first boranophosphorothioate [(RO)₂P(S)(BH₃)^–] mimic of a phosphodiester compound, dithymidine boranophosphorothioate, has been synthesized; while it is water soluble, this new analogue is more lipophilic and nuclease resistant than natural nucleoside phosphodiesters [(RO)₂P(O)(O)^–] and phosphorothioates [(RO)₂P(S)(O)^–].

References

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