DOI: 10.1039/A901140D
(Paper)
Reference Section for: Chem. Commun., 1999, 1147-1148
Novel reagents for targeted cleavage of RNA sequences: towards a new family of inorganic pharmaceuticals
(Note: The full text of this document is currently only available in the PDF Version )
Alavattam Sreedhara, Anjali Patwardhan and J. A. Cowan
Abstract
Copper kanamycin degrades cognate RNA targets at concentrations as low as picomolar levels at physiological pH and temperature, but shows no chemistry with random RNA or DNA molecules, thereby demonstrating potential for development as a novel antiviral agent.
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