A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications

Abstract

The ability of the paramagnetic macromolecular complex (GdDO3ASQ)₃₀-Orn₁₁₄ to enhance the water proton relaxation rate has been found to be a function of pH; this behaviour is related to the structural changes occurring in the polypeptide upon protonation of the side-chain NH₂ groups.

References

1. J. A. Peters, J. Huskens and D. J. Raber, Prog. Nuc. Magn. Reson. Spectrosc., 1996, 28, 283.
2. S. Aime, M. Botta, M. Fasano and I. Terreno, Chem. Soc. Rev., 1997, 26, 1.
3. D. Parker and J. A. G. Williams, J. Chem. Soc., Dalton Trans., 1996, 3613.
4. J. A. Meyer, Am. Surg., 1974, 179, 88.
5. S. H. Koenig and R. D. Brown III, Prog. Nucl. Magn. Reson. Spectrosc., 1990, 22, 487.
6. L. F. Tietze, C. Schroter, S. Gabius, U. Brinck, A. Goerlach-Graw and H. J. Gabius, Bioconjugate Chem., 1991, 2, 48.
7. S. Aime, M. Botta, S. Geninatti Crich, G. Giovenzana, G. Palmisano and M. Sisti, Bioconjugate Chem., 1999, 10, 192.
8. P. F. Sieving, A. D. Watson and M. R. Rocklage, Bioconjugate Chem., 1990, 1, 65.
9. A. D. Sherry, W. P. Cacheris and K. T. Kuan, Magn. Reson. Med., 1988, 8, 180.
10. R. B. Lauffer, Chem. Rev., 1987, 87, 901.
11. J. Hall, R. Häner, S. Aime, M. Botta, S. Faulkner, D. Parker and A. S. de Sousa, New J. Chem., 1998, 627.
12. R. J. Gillies, Z. Liu and Z. Bhujwalla, Am. J. Physiol., 1994, C195.
13. Y. Aoki, K. Akagi, Y. Tanaka, J. Kawai and M. Takahashi, Invest. Radiol., 1996, 31, 680.