Signal transduction mediated by artificial cell-surface receptors: activation of lactate dehydrogenase triggered by molecular recognition and phase reorganization of bile acid derivatives embedded in a synthetic bilayer membrane

Abstract

A bile acid derivative, N-(2-aminoethyl)-5β-cholan-24-amide, acts as an artificial cell-surface receptor capable of activating lactate dehydrogenase by performing double signal recognition and phase reorganization in a synthetic bilayer membrane.

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