DOI: 10.1039/A809791G
(Paper)
Reference Section for: Chem. Commun., 1999, 797-798
Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity
(Note: The full text of this document is currently only available in the PDF Version )
Stephen J. Gregson, Philip W. Howard, David E. Thurston, Terence C. Jenkins and Lloyd R. Kelland
Abstract
A C2/C2′-exo unsaturated pyrrolobenzodiazepine dimer 1 has been synthesised which is cytotoxic at the picomolar level and has remarkable covalent DNA binding affinity, raising the melting temperature of duplex-form calf thymus DNA by 34 °C after 18 h incubation.
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