Stereoselectivity in the double reductive alkylation of pyrroles: synthesis of cis-3,4-disubstituted pyrrolidines

Abstract

The preparation and Birch reduction of a 1,3,4-tri-substituted pyrrole is described: the heterocycle is loaded with electron-withdrawing groups and undergoes a double reductive alkylation reaction to yield cis-3,4-disubstituted pyrrolidines.

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