Efficient site-specific cleavage of RNA using a terpyridine–copper(II) complex joined to a 2′-O-methyloligonucleotide by a non-flexible linker

Abstract

A terpyridine–Cu(II) complex conjugated to an antisense 2′-O-methyloligonucleotide at the 5′-end cleaved RNA predominantly at the site opposite the 5′-end in moderate yield, but the cleavage yield increased by more than two-fold when a 2′-O-methyloligonucleotide was allowed to bind to the single-stranded region of the RNA-antisense complex.

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