Total synthesis of (+)-pramanicin and stereochemical elucidation of the natural product

Abstract

Total synthesis of (+)-pramanicin is achieved through a ‘one pot’ Michael addition of an aminosilyl zincate species to an α,β-unsaturated lactam and quenching of the resultant enolate with an α,β-unsaturated γ,δ-epoxy aldehyde.

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