15-Deoxy-16-(m-tolyl)-17,18,19,20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells

Abstract

Biologically remarkable 15-deoxy-TIC has been realised by the removal of the C(15) chiral centre in 15R-TIC, a stable ligand for a CNS-type prostacyclin receptor (IP₂); this deoxy derivative exhibits ten-fold higher affinity and selectivity than 15R-TIC for the IP₂ receptor in correlation with the anti-apoptotic activity for neuronal cells.

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