Combining four different model nucleobases (uracil, adenine, guanine, cytosine) via metal binding and H bond formation in a single compound

(Note: The full text of this document is currently only available in the PDF Version )

Roland K. O. Sigel, Susan M. Thompson, Eva Freisinger and Bernhard Lippert


Abstract

A cyclic arrangement of the four model nucleobases 1-methyluracilate (mura), 9-ethyladenine (eade), 9-ethylguanine (Hegua) and 1-methylcytosine (mcyt), held together by two metal entities [trans-(NH3)2PtII and trans-(MeNH2)2PtII] and multiple H bond interactions, is presented.


References

  1. O. Krizanovic, M. Sabat, R. Beyerle-Pfnür and B. Lippert, J. Am. Chem. Soc., 1993, 115, 5538 CrossRef CAS.
  2. A. Schreiber, M. S. Lüth, A. Erxleben, E. C. Fusch and B. Lippert, J. Am. Chem. Soc., 1996, 118, 4124 CrossRef CAS; S. Metzger, A. Erxleben and B. Lippert, J. Biol. Inorg. Chem., 1997, 2, 256 CrossRef CAS; M. S. Lüth, E. Freisinger, F. Glahé, J. Müller and B. Lippert, Inorg. Chem., 1998, 37, 3195 CrossRef.
  3. M. S. Lüth, E. Freisinger, F. Glahé and B. Lippert, Inorg. Chem., 1998, 37, 5044 CrossRef.
  4. B. Lippert, J. Chem. Soc., Dalton Trans., 1997, 3971 RSC and references therein C. Meiser, E. Freisinger and B. Lippert, J. Chem. Soc., Dalton Trans., 1998, 2059 Search PubMed; R. K. O. Sigel, E. Freisinger and B. Lippert, Chem. Commun., 1998, 219 RSC; R. K. O. Sigel, E. Freisinger, S. Metzger and B. Lippert, J. Am. Chem. Soc., in press RSC.
  5. M. Rossi, J. P. Caradonna, L. G. Marzilli and A. T. Kistenmacher, Adv. Mol. Relax. Interact Process, 1979, 15, 103 Search PubMed.
  6. E. J. O'Brien, J. Mol. Biol., 1963, 7, 107 CAS.
  7. A. Schreiber, E. C. Hillgeris, A. Erxleben and B. Lippert, Z. Naturforsch., Teil B, 1993, 48, 1603 CAS; S. Jaworski, S. Menzer, B. Lippert and M. Sabat, Inorg. Chim. Acta, 1993, 205, 31 CrossRef CAS.
  8. A. Hegmans, M. Sabat, I. Baxter, E. Freisinger and B. Lippert, Inorg. Chem., 1998, 37, 4921 CrossRef CAS.
  9. J. H. Cate, A. R. Gooding, E. Podell, E. Zhou, B. L. Golden, A. A. Szewczak, C. E. Kundrot, T. R. Cech and J. A. Doudna, Science, 1996, 273, 1696 CAS and references therein.
  10. NONIUS BV, KappaCCD package, Röntgenweg 1, P.O.Box 811, 2600 AV Delft, Netherlands; Z. Otwinowsky and W. Minor, Processing of X-ray Diffraction Data Collected in Oscillation Mode, Methods in Enzymology, ed., C. W. Carter, Jr. and R. M. Sweet, Academic Press, 1996, 276, 307 Search PubMed.
  11. G. M. Sheldrick, Acta Crystallogr., Sect. A, 1990, 46, 467 CrossRef.
  12. G. M. Sheldrick, SHELXL-93, Program for crystal structure refinement, University of Göttingen, Germany, 1993.
Click here to see how this site uses Cookies. View our privacy policy here.