View PDF Version
 
DOI: 10.1039/A907400G (Paper) Reference Section for: Analyst, 1999, 124, 1589-1593

An HPLC assay for the determination of ketoconazole in common pharmaceutical preparations

(Note: The full text of this document is currently only available in the PDF Version )

A. S. Low and J. Wangboonskul

Abstract

An HPLC method is described using octadecylsilica (3 µm) with an acetonitrile phosphate buffer mobile phase containing diethylamine which is capable of separating ketoconazole [(±)-cis-1-acetyl-4-(4{[2-(dichlorophenyl)-2- (1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine] from four related compounds, (R049223, R063600, R053165 and R039519) and from excipients in tablets, cream and shampoo. The method was validated using an external calibration method for tablets, shampoo and creams and a standard addition method for cream. The limits of detection for the related compounds in the presence of ketoconazole are also reported.

References

  1. British Pharmacopoeia, HM Stationery Office, London, 1998 Search PubMed.
  2. O. Shakoor, R. B. Taylor and R. H. Behrens, Trop. Med. Int. Health, 1997, 2, 839 CAS.
  3. M. A. Abounassif and B. E. D. M. El Shazly, Anal. Lett., 1990, 22, 2233.
  4. M. A. Al Meshal, Anal. Lett., 1990, 22, 2249.
  5. Z. Jiang, X. Weng and L. Lu, Yaowu Fenxi Zazhi, 1990, 10, 161 Search PubMed.
  6. S. S. Zarapkar and U. P. Halkar, Indian Drugs, 1991, 28, 265 Search PubMed.
  7. F. Dai and L. Li, Yaowu Fenxi Zazhi, 1990, 10, 232 Search PubMed.
  8. E. R. M. Kedor Hackmann, M. N. F. Nery and M. I. R. M. Santoro, Anal. Lett., 1994, 27, 363.
  9. C. X. Zhang, F. von Heeren and W. Thormann, Anal. Chem., 1995, 67, 2070 CrossRef CAS.
  10. Z. X. Xia, S. M. Lan and Z. M. Zhan, Yaowu Fenxi Zazhi, 1995, 15, 42 Search PubMed.
  11. L. W. Whitehouse, A. Menzies, B. Dawson, T. D. Cyr, A. W. By, D. B. Black and J. Zamecnik, J. Pharm. Biomed. Anal., 1994, 12, 1425 CrossRef CAS.
  12. F. M. Abdel Gawad, Farmaco, 1997, 52, 119.
  13. U. Roychowdhury and S. K. Das, J. AOAC Int., 1996, 79, 656 CAS.
  14. A. El Bayoumi, A. A. El Shanawany, M. E. El Sadek and A. Abd El Sattar, Spectrosc. Lett., 1997, 30, 25.
  15. K. H. Yuen and K. K. Peh, J. Chromatogr. B., Biomed. Appl., 1998, 715, 436 CrossRef CAS.
  16. K. B. Alton, J. Chromatogr. B, Biomed. Appl., 1980, 10, 337 CrossRef.
  17. F. A. Andrews, L. R. Peterson, W. H. Beggs, D. Crankshaw and G. A. Sarosi, Antimicrob. Agents Chemother., 1981, 19, 110 CAS.
  18. S. F. Swezey, K. M. Giacomini, A. Abang, C. Brass, D. A. Stevensand and T. F. Blaschke, J. Chromatogr. B, Biomed. Appl., 1982, 16, 510 CrossRef.
  19. N. R. Badcock, J. Chromatogr. B, Biomed. Appl., 1983, 20, 436.
  20. V. L. Pascucci, J. Bennett, P. K. Narang and D. C. Chatterji, J. Pharm.Sci., 1983, 72, 1467 CAS.
  21. C. M. Riley and M. O. James, J. Chromatogr. B, Biomed. Appl., 1986, 4, 287 CrossRef.
  22. C. A. Turner, A. Turner and D. W. Warnock, J. Antimicrob.Chemother., 1986, 18, 757 CAS.
  23. D. W. Hoffman, K. L. Jones King, C. L. Ravaris and R. D. Edkins, Anal. Biochem., 1988, 172, 495 CAS.
Click here to see how this site uses Cookies. View our privacy policy here.