Experimental demonstration and simulation of electrochemical non-linear responses to glucose and its interferents with an amperometric sensor

Abstract

A novel sensing system based on the multi-dimensional information contained in a dynamic non-linear response is proposed. A sinusoidal potential was applied to an amperometric-type glucose sensor and the resulting current of the sensor was analyzed by fast Fourier transformation (FFT). The amplitudes of the higher harmonics of FFT characterize the non-linear properties of the response. The amplitudes of the higher harmonics of FFT exhibit characteristic changes which depend on the concentration and the kinetics of the reactions of glucose and its interferents at the sensor surface. The essential features of the current–potential curve were reproduced by a computer simulation based on the kinetics of electrochemical reactions.

References

1. Biosensors: Fundamentals and Applications, ed. A. P. F. Turner, I. Karube and G. S. Wilson, Oxford University Press, Oxford, 1987.
2. R. P. Buck, W. E. Hatfield, M. Umaña and E. F. Bowden, in Biosensor Technology: Fundamentals and Application, Marcel Dekker, New York, 1990.
3. F. Scheller and F. Schbert, in Biosensors, Elsevier, Amsterdam, 1992.
4. D. G. Buerk, Biosensors. Theory and Applications, Technomic Publishing, Lancaster, PA, 1993.
5. R. Maidan and A. Heller, J. Am. Chem. Soc., 1991, 113, 9003.
6. T. Ohsaka, Y. Yamaguchi and N. Oyama, Bull. Chem. Soc. Jpn., 1990, 63, 2646.
7. L. C. Guerente, A. Deronzier, P. Mailley and J. C. Moutet, Anal. Chim. Acta, 1994, 289, 143.
8. N. Oyama, T. Osaka, M. Mizunuma and M. Kobayashi, Anal. Chem., 1988, 60, 2534.
9. H. Liu and J. Deng, Biosens. Bioelectron., 1996, 11, 103.
10. A. E. G. Cass, G. Davis, G. D. Francis, H. A. O. Hill, W. J. Aston, I. J. Higgins, E. V. Plotkin, L. D. L. Scott and A. P. F. Turner, Anal. Chem., 1984, 56, 667.
11. A. L. Crumbliss, H. A. O. Hill and D. J. Page, J. Electroanal. Chem., 1986, 206, 327.
12. I. Willner and A. Riklin, Anal. Chem., 1994, 66, 1535.
13. J. Svorc, S. Miertus, J. Katrlik and M. Stredansky, Anal. Chem., 1997, 69, 2086.
14. S. Nakata, N. Kido, M. Hayashi, M. Hara, H. Sasabe, T. Sugawara and T. Matsuda, Biophys. Chem., 1996, 62, 63.
15. S. Nakata, S. Akakabe, M. Nakasuji and K. Yoshikawa, Anal. Chem., 1996, 68, 2067.
16. S. Nakata, E. Ozaki and N. Ojima, Anal. Chim. Acta, 1998, 361, 93.
17. S. Nakata, Y. Hirata, R. Takitani and K. Yoshikawa, Chem. Lett., 1998, 401.
18. S. Nakata, R. Takitani and Y. Hirata, Anal. Chem., 1998, 70, 4304.
19. A. J. Bard and L. R. Faulkner, Electrochemical Methods, Wiley, New York, 1980.
20. D. E. Smith, Anal. Chem., 1963, 35, 610.
21. D. E. Smith and T. G. McCord, Anal. Chem., 1968, 40, 474.
22. A. V. Sorkirko and F. H. Bark, Electrochim. Acta, 1995, 40, 1983.
23. T. Tatsuma and T. Watanabe, Anal. Chem., 1992, 64, 625 and 630.
24. B. R. Eggins, Biosensors: an Introduction, Wiley and Teubner, 1996.
25. U. E. Sprichiger-Keller, Chemical Sensors and Biosensors for Medical and Biological Applications, Wiley-VCH, Weinheim, 1998.
26. M. Jänchen, G. Walzel, B. Neef, B. Wolf, F. Scheller, M. Kühn, D. Pfeiffer, W. Sojka and W. Jaross, Biomed. Biochim. Acta, 1983, 42, 1055.
27. M. Nanjo and G. G. Guilbault, Anal. Chem., 1974, 46, 1769.