Flow injection analysis–direct chemiluminescence determination of ergonovine maleate enhanced by hexadecylpyridinium chloride

Abstract

A flow injection analysis–direct chemiluminescence method is proposed for the determination of ergonovine maleate, based on the oxidation of the drug by hexacyanoferrate(III) in sodium hydroxide. The chemiluminescence was enhanced by a cationic surfactant, hexadecylpyridinium chloride. The calibration graph was linear over the range from the limit of detection (70 ppt) to 1 ppm of ergonovine maleate, with an RSD (n = 50, 50 ppb) of 1.8% and a sample throughput of 118 h^–1. The influence of foreign compounds was tested. The method was applied to the determination of ergonovine maleate in synthetic samples.

References

1. Martindale, The Extra Pharmacopoeia, Pharmaceutical Press, London, 6th edn., 1972.
2. D. van Reif, Analytical Profiles of Drug Substances, Academic Press, Orlando, 1982, vol. 11, p. 273.
3. Official Methods of Analysis of the AOAC, ed. S. Williams, AOAC, Washington, DC, 14th edn., 1985.
4. A. Mellado Romero, C. Gómez Benito and J. Martínez Calatayud, Anal. Chim. Acta, 1993, 282, 95.
5. D. Y. Zhao, F. Y. Chen and W. R. Wei, Zhongguo YaoXue Zahzi, 1992, 27, 666.
6. R. A. Shelby and V. C. Kelley, J. Agric. Food Chem., 1992, 40, 1090.
7. R. A. Shelby and V. C. Kelley, Agric. Food Immunol., 1991, 3, 169.
8. F. Belal and J. L. Anderson, Talanta, 1986, 33, 448.
9. J. Martínez Calatayud and S. Sagrado Vives, Pharmazie, 1989, 44, 614.
10. P. J. Worsfold and K. Robards, Anal. Chim. Acta, 1992, 266, 147.
11. A. Townshend, Analyst, 1990, 115, 495.
12. J. Martínez Calatayud, Flow Injection Analysis of Pharmaceuticals. Automation in the Laboratory, Taylor and Francis, London, 1996, p. 171.
13. P. J. Worsfold, A. R. Bowie and M. G. Sanders, J. Biolumin. Chemilumin., 1996, 11, 61.
14. B. Fernandez Band, Y. Fuster Mestre, L. Lahuerta Zamora, G. M. Antón-Fos, R. Garcia Domenech and J. Martinez Calatayud, paper presented at the VIII International Symposium on Luminescence Spectrometry in Biomedical and Environmental Analysis—Detection Techniques and Applications in Chromatography and Capillary Electrophoresis, Las Palmas de Gran Canaria, Spain, May 1998.
15. J. Galvéz, R. García, J. V. Julian, C. De Gregorio and R. Soler, New Antibacterial Drugs Designed by Molecular Connectivity. Advances in Molecular Similarity, ed. R. Carbo-Dorca and P. G. Mezey, JAL Book Series I, Greenwich, CT, 1996.
16. M. P. Arviza, PhD Thesis, University of Valencia, 1985.
17. A. C. Calokerinos and N. Grekas, Talanta, 1990, 37, 1043.
18. A. C. Calokerinos and A. B. Syropoulos, Anal. Chim. Acta, 1991, 255, 403.
19. W. P. Yang, B. L. Li, Z. J. Zhang and G. H. Tian, Fenxi Huaxue, 1996, 24, 579.
20. A. A. Alwarthan, H. A. Al Lohedan and Z. A. Issa, Anal. Lett., 1996, 29, 1589.
21. Z. D. Zhang, W. Baeyens, X. R. Zhang, A. C. Calokerinos and G. Van der Weken, Biomed. Chromatogr., 1995, 9, 287.
22. Y. Zhao, W. R. G. Baeyens, X.-R. Zhang, A. C. Calokerinos, K. Nakashima and G. Van Der Weken, Analyst, 1997, 122, 103.
23. S. L. Morgan and S. N. Deming, Anal. Chim. Acta, 1974, 46, 1170.
24. British Pharmacopoeia, HM Stationery Office, London, 1993.