A top-down in-house validation based approach for the investigation of the measurement uncertainty using fractional factorial experiments

Abstract

The recently presented in-house validation concept developed on the basis of a variance component model is extended and optimised by basing it on a fractional factorial sampling scheme. The presented approach relies on a comprehensive mathematical model to assess simultaneously the in-house reproducibility and its components in addition to uncertainty-related performance characteristics like power functions and critical concentrations. The influence of individual factors and the corresponding uncertainties can be determined separately in a single experiment with optimum utilization of the generated data, in this way achieving a favourable ratio between costs and result.

References

1. International Organization for Standardization, Guide to the Expression of Uncertainty in Measurement, ISO, Geneva, 1st edn., 1995.
2. Quantifying Uncertainty in Analytical Measurement, EURACHEM Secretariat, Teddington, 1995.
3. Analytical Methods Committee, Analyst, 1995, 120, 2303.
4. S. L. R. Ellison and V. J. Barwick, Analyst, 1998, 123, 1387.
5. W. Horwitz, J. AOAC Int., 1998, 81, 785.
6. B. Jülicher, P. Gowik and S. Uhlig, Analyst, 1998, 120, 173.
7. P. Gowik, B. Jülicher and S. Uhlig, J. Chromatogr., 1998, 716, 221.
8. S. Ellison, W. Wegscheider and A. Williams, Anal. Chem., 1997, 607A.
9. M. Thompson, Accred. Qual. Assur., 1998, 3, 117.