Total synthesis of the protein phosphatase inhibitor okadaic acid

Abstract

The total synthesis of the protein phosphatase inhibitor okadaic acid 1 is reported using a convergent coupling strategy of three components, all of which may be prepared using chemistry developed in our laboratories.

References

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30. Authentic okadaic acid was kindly provided by Professor K. Yamada and Professor D. Uemura. Comparison between the synthetic and authentic compounds was made by superposition of the corresponding 600 MHz ¹H NMR spectra, co-elution by thin layer chromatography and electrospray accurate mass spectrometry.