Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents

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Jörg Habermann, Steven V. Ley and James S. Scott


Abstract


References

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  13. Yield for reaction from precursor compound.
  14. Masses given are obtained in positive mode and are M + H or in some cases M + NH4. No mass ions were observed for compounds 2b and 2d under ES-MS conditions.
  15. cis:trans ratio by separation was determined to be ∼1∶2.
  16. Quantitative on 40 mg scale, 74% on 200 mg scale.
  17. About 60% conversion after 2 days, but reaction does not go to completion on extended reaction time.
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