Asymmetric syntheses of moiramide B and andrimid

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Stephen G. Davies and Darren J. Dixon


Abstract

The first highly diastereoselective asymmetric syntheses of moiramide B 2 and andrimid 3 have been achieved using lithium amide (R)-6 and pyrrolidinone auxiliary (R)-9. Pyrrolidinone auxiliary (R)-9 was used to create the novel (S[hair space])-3-methyl-N-benzyloxysuccinimide (S[hair space])-11 which was subsequently acylated with the highly reactive tert-butoxycarbonyl-protected N-carboxy anhydride of L-valine (Boc-val-NCA) (S[hair space])-19 under strongly basic conditions, without racemisation. Lithium amide (R)-6 was used to synthesise homochiral D-β-phenylalanine tert-butyl ester 25.


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