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DOI: 10.1039/A804340J (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1998, 3851-3856

Polycyclic N-heterocyclic compounds. Part 52.1 One-step syntheses of imidazo[1,5-a]pyridines, imidazo[1,5-a]quinolines and imidazo[5,1-a]isoquinolines by Vilsmeier reactions of pyridine-2-carbonitriles, quinoline-2-carbonitriles and isoquinoline-1-carbonitriles

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Kenji Sasaki, Akifumi Tsurumori and Takashi Hirota

Abstract

The versatile, one-step synthesis of imidazo[1,5-a]pyridines by the reaction of pyridine-2-carbonitriles with DMF under Vilsmeier conditions is described. This reaction was applied to the syntheses of imidazo[1,5-a]quinolines from quinoline-2-carbonitriles, and of imidazo[5,1-a]isoquinolines from isoquinoline-1-carbonitriles.

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