A one-step synthesis of 1-substituted thieno[2,3-f  ]benzo[cd ]indol-4-ones via benzyne-3-carboxylate

Abstract

4-Substituted bromobenzoic acids react with 3-thienylacetonitrile under aryne-forming conditions (LDA) to give the corresponding thieno[2,3-f  ]benzo[cd ]indol-4-ones; this constitutes the first reported synthesis of this heretofore unknown tetracyclic heterocycle.

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