Synthesis of elenic acid, an inhibitor of topoisomerase II from the sponge Plakinastrella sp.

Abstract

(R)-(–)-Elenic acid 1, an inhibitor of topoisomerase II isolated from the marine sponge Plakinastrella sp., has been synthesized starting from hexadecane-1,16-diol 2 and methyl (S )-3-hydroxy-2-methylpropanoate 6.

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