A new route to ene carbamates, precursors to benzoindolizinones through sequential asymmetric hydrogenation and cyclization

Abstract

New pyrrolidine-based ene carbamates have been efficiently synthesized and the first example of asymmetric hydrogenation of this kind of substrate is reported, leading to the preparation of 2-arylmethylpyrrolidine precursors to benzoindolizinones in high yields and enantioselectivities up to 57%.

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