Practical enantiodivergent syntheses of both enantiomers of carbovir, 1592U89 and six-membered ring analogues

Abstract

The hydroxylactones 4a–b (both available in optically pure form from biocatalytic processes) have been used in the preparation of carbovir, 1592U89, and their six-membered ring analogues.

References

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21. Carbovir^{ref. 11}(1a): [a]_D–62 (c 0.4, MeOH); 1592U89^{ref. 2e}(2a): [a]_D–31.8 (c 0.51, MeOH); homocarbovir (1b): [a]_D–26.8 (c 0.53, MeOH); homo-1592U89 (2b): [a]_D–37.3 (c 0.18, MeOH).