A palladium(>0>)-mediated approach to some novel C-4-substituted Neu5Ac2en derivatives

Abstract

The preparation of a range of novel C-4-modified 2,3-unsaturated N-acetylneuraminic acid analogues is reported. These compounds have been prepared from the 4-chloro-4-deoxy-N-acetylneuraminic acid derivatives 10 and 12 by using a palladium(>0>)-mediated coupling with organostannanes.

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