Synthesis and metal complexation of chiral 3-mono- or 3,3-bis-allyl-2-hydroxypyrrolopyrazine-1,4-diones

Abstract

A novel synthesis of chiral cyclic hydroxamic acids (4, 6, 8 and 10) related to cyclodipeptides is described. The crucial reduction of the nitro group of the N-nitroacetyl derivatives of (S )-α-amino acid esters is brought about by zinc–aq. ammonium chloride. The Fe^III and Cu^II complexes of one such cyclic hydroxamic acid 10a have been prepared and their DNAse activity investigated.

References

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