View PDF Version
 
DOI: 10.1039/A707093D (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1998, 3-6

Structure of the nogalamycin–d(ATGCAT)2 complex in solution: DNA recognition at an isolated TpG site

(Note: The full text of this document is currently only available in the PDF Version )

Huw E. Williams and Mark S. Searle

Abstract

The solution structure of the 1∶1 nogalamycin–d(ATGCAT)2 complex, determined from high resolution NMR data and refined using restrained molecular dynamics, reveals details of the interaction and preferred orientation of the antibiotic at its high affinity 5′-TpG intercalation site.

References

  1. J. F. Fisher and P. A. Aristoff, Prog. Drug. Res., 1988, 32, 411 Search PubMed.
  2. M. S. Searle, J. G. Hall, W. A. Denny and L. P. G. Wakelin, Biochemistry, 1988, 27, 4340 CrossRef CAS.
  3. K. R. Fox, C. Brasset and M. J. Waring, Biochem. Biophys. Acta, 1985, 840, 383 Search PubMed.
  4. B. K. Bhuyan and A. Dietz, Antimicrob. Agents Chemother., 1965, 836 CAS; B. K. Bhuyan and F. Reusser, Cancer Res., 1970, 30, 948; L. H. Li, S. L. Kuentzel, L. L. Murch, L. M. Pschigoda and W. C. Krueger, Cancer Res., 1979, 39, 4816 CAS.
  5. H. Ennis, Antimicrob. Agents Chemother., 1981, 19, 657 CAS.
  6. K. R. Fox and M. J. Waring, Biochemistry, 1986, 25, 4349 CrossRef CAS.
  7. Y.-C. Liaw, Y.-G. Gao, H. Robinson, G. A. van der Marel, J. H. van Boom and A. H.-J. Wang, Biochemistry, 1989, 28, 9913 CrossRef CAS.
  8. L. D. Williams, M. Egli, Q. Gao, P. Bash, G. A. van der Marel, J. H. van Boom, A. Rich and C. A. Frederick, Proc. Natl. Acad. Sci. USA, 1990, 87, 2225 CAS.
  9. Y.-G. Gao, Y.-C. Liaw, H. Robinson and A. H.-J. Wang, Biochemistry, 1990, 29, 10 307 CrossRef CAS.
  10. M. Egli, L. D. Williams, C. A. Frederick and A. Rich, Biochemistry, 1991, 30, 1364 CrossRef CAS.
  11. C. K. Smith, G. J. Davies, E. J. Dodson and M. H. Moore, Biochemistry, 1995, 34, 415 CrossRef CAS.
  12. C. K. Smith, J. A. Brannigan and M. H. Moore, J. Mol. Biol., 1996, 263, 237 CrossRef CAS.
  13. G. S. Schuerman, C. K. Smith, J. P. Turkenburg, A. N. Dettmar, L. Van Meervelt and M. H. Moore, Acta Crystallogr., Sect. D, 1996, 52, 299 CrossRef.
  14. X. Zhang and D. J. Patel, Biochemistry, 1990, 29, 9451 CrossRef CAS.
  15. M. S. Searle and W. Bicknell, Eur. J. Biochem., 1992, 205, 45 CAS.
  16. H. Robinson, Y.-C. Liaw, G. A. van der Marel, J. H. van Boom and A. H.-J. Wang, Nucleic Acids Res., 1990, 18, 4851 CAS.
  17. D. A. Pearlman, D. A. Case, J. W. Caldwell, W. S. Ross, T. E. Cheatham, D. M. Fergusson, G. L. Seibel, U. C. Singh, P. K. Weiner and P. A. Kollman, AMBER 4.1, 1995, University of California, San Francisco, 1995.
  18. T. E. Cheatham, J. L. Millar, T. Fox, T. A. Darden and P. A. Kollman, J. Am. Chem. Soc., 1995, 117, 4193 CrossRef CAS.
  19. R. Koradi, M. Billeter and K. Wuthrich, J. Mol. Graphics, 1996, 14, 51 CrossRef CAS.
  20. M. S. Searle, Prog. Nucl. Magn. Reson. Spect., 1993, 25, 403 Search PubMed.
  21. D. J. Patel, L. Shapiro and D. Hare, Quat. Rev. Biophys., 1987, 20, 35 Search PubMed.
  22. R. V. Hosur, G. Govil and H. T. Miles, Magn. Reson. Chem., 1988, 26, 927 CAS.
  23. J. D. Beleja, J. Moult and B. D. Sykes, J. Magn. Reson., 1990, 87, 375.
  24. SPARTAN 3.1, 1994–1995, Wavefunction Inc., USA.
Click here to see how this site uses Cookies. View our privacy policy here.