Regioselective Dieckmann cyclisations leading to enantiopure highly functionalised tetramic acid derivatives

Abstract

Regioselective Dieckmann cyclisations using an N-acyloxazolidine derived from L-serine give substituted tetramic acids in high yield and enantioselectivity. The products are easily deprotected under mild conditions to give hydroxymethyltetramic acids.

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