Palladium-catalysed heteroannulation with terminal alkynes: synthesis of phthalides ¹

Abstract

The palladium–copper-catalysed heteroannulation of o-iodobenzoic acid 3 with terminal alkynes 4–18 leads to the synthesis of (Z)-3-alkylidenephthalides 19–33 as the major products. In certain cases, the formation of isocoumarins 34–37 is also observed.

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