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DOI: 10.1039/A703660D (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1998, 359-366

Synthesis of hexapeptide and tetrapeptide analogues of the immunomodulating peptides

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Ju Young Lee, Yong Jun Chung, Yoe-Sik Bae, Sung Ho Ryu and Byeang Hyean Kim

Abstract

Two hexapeptide and two tetrapeptide analogues of the bioactive hexapeptides [(Trp/Met/Phe)-Lys-Tyr-(Met/Val[hair space])-(Pro/Val)-Met] have been synthesized by incorporating novel peptide isosteres such as 2-isoxazoline, (E[hair space])-alkene, and reduced amide isosteres. These immunomodulating hexapeptides are known to stimulate the formation of inositol phosphates in lymphocyte cell lines.

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