1,2-Asymmetric induction in nucleophilic Michael addition reactions of amines under microwave irradiation

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Nelli N. Romanova , Alexandr G. Gravis , Irina F. Leshcheva and Yurii G. Bundel'


Abstract

1,2-Asymmetric induction of up to 76% is observed in the reactions of several amines with the β-substituted acrylic acid ester (S)-1 containing a γ-asymmetric carbon atom in the absence of solvent after 12 min microwave irradiation.


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