DOI: 10.1070/MC1998v008n05ABEH000954
(Paper)
Mendeleev Commun., 1998, 8, 183-184
Direct synthesis of 17a-ethoxyimino-8-aza-D-homogonanes by annelation of 3,4-dihydroisoquinolines with 2-acetyl-5,5-dimethyl-3-ethoxyiminocyclohexanone
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Olga V. Gulyakevich , I L. Rubinova , Dmitry B. Rubinov and Alexander L. Mikhal'chuk
Abstract
The annelation reaction of Schiff bases by ββ'-tricarbonyl compounds has been extended to 3-ethoxyimino derivatives of 2-acyl-cyclohexane-1,3-diones. The first direct synthesis of 8-aza-D-homogonanes with a modified carbonyl group at the pharmacologically significant C(17a) position has been carried out.