Synthesis of Potential Thromboxane A₂ Antagonists based on the Azabicyclo[2.2.1]heptane Skeleton

Abstract

Thirteen compounds having a 2-aza- or a 7-azabicyclo[2.2.1]heptane framework substituted at the 3-position by a prostanoic chain have been synthesized from easily obtained hetero-Diels–Alder adducts; owing to their structure, a TxA₂ antagonist activity was expected for these compounds with consequences for platelets aggregation and/or blood pressure, and these effects were effectively observed for some of them but with lower activity than previously described molecules.

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