Solution Structure and Assignments of the 1H and 13C NMR Spectra of Erythromycin C in Organic and Aqueous Solution

(Note: The full text of this document is currently only available in the PDF Version )

Paul Tyson, Hervé Barjat, Warren Mann and Jill Barber


Abstract

Erythromycin C (1) has been shown to exist as a 4:5 equilibrium mixture of the 9-ketone and 12,9-hemiacetal ring-chain tautomers in aqueous solution at ambient temperature.


References

  1. J. Barber, J. I. Gyi, L. Lian, G. A. Morris, D. A. Pye and J. K. Sutherland, J. Chem. Soc., Perkin Trans. 2, 1991, 1489 RSC.
  2. P. Kurath, P. H. Jones, R. S. Egan and T. J. Perun, Experientia, 1971, 27, 362 Search PubMed.
  3. P. F. Wiley, K. Gerzon, E. H. Flynn, M. V. Sigal, Jr., O. Weaver, U. C. Quarck, R. R. Chauvette and R. Monohan, J. Am. Chem. Soc., 1957, 79, 6062 CrossRef CAS.
  4. R. J. Brennan, A. Awan, J. Barber, E. Hunt, K. L. Kennedy and S. Sadegholnejat, J. Chem. Soc., Chem. Commun., 1994, 1615 RSC.
Click here to see how this site uses Cookies. View our privacy policy here.