A Practical Synthesis of 2,6-Dicarboxyfluorenone

Abstract

Herein, we report a new and efficient method for the large scale synthesis of 2,6-dicarboxyfluorenone 5 in 95% yield using 0.01mol% of bis(triphenylphosphine)palladium(II) chloride, (PPh₃)₂ PdCl₂, as a catalyst, starting with the reaction of 2,5-dimethylbromobenzene and 4-bromotoluene to give 2,4,5-trimethylbiphenyl 3, followed by oxidation and then cyclization.

References

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