Novel Enone–Benzene Rearrangement of 4,4-Dialkylcholest-5-en-3-ones to Ring-B Aromatic Steroidal Hydrocarbons Catalysed by p-Toluenesulfonic acid

(Note: The full text of this document is currently only available in the PDF Version )

Hui-Yun Duan and Tong-Shuang Li


Abstract

A new by-product, 6-methyl-3-isopropyl-A,19-dinorcholesta-6,8,10(5)-triene has been identified from the reaction of 4,4-dimethylcholest-5-en-3-one catalysed by p-toluenesulfonic acid in refluxing toluene, revealing a novel enone–benzene rearrangement.


References

  1. Y. Sato, A. Mizuguchi, S. Tanaka and K. Tsuda, Chem. Pharm. Bull., 1965, 13, 393 CAS.
  2. P. Bey, F. Lederer and G. Ourisson, Chem. Pharm. Bull., 1965, 13, 1138 CAS.
  3. P. Bey and G. Ourisson, Bull. Soc. Chim. Fr., 1968, 1402 CAS.
  4. J. Overnell and J. S. Whitehurst, J. Chem. Soc. C, 1971, 378 RSC.
  5. G. Hussler, B. Chappe, P. Wehrung and P. Albrecht, Nature (London), 1981, 294, 556 CAS.
  6. G. Hussler and P. Albrecht, Nature (London), 1983, 304, 262 CAS.
  7. T. S. Li, J. Hebei Univ., Natural Sci. Ed., 1996, 16, 71 Search PubMed.
  8. N. W. Atwater, J. Am. Chem. Soc., 1960, 82, 2847 CrossRef CAS.
  9. T. S. Li, J. T. Li and H. Z. Li, J. Chromatogr., A, 1995, 715, 372 CrossRef CAS.
Click here to see how this site uses Cookies. View our privacy policy here.