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DOI: 10.1039/A802837K (Paper) Reference Section for: J. Chem. Res. (S), 1998, 756-757

Synthesis of Acyclonucleoside Derivatives of 5-Alkoxymethyluracils

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Ahmed El-Sayed Abdel-Megied

Abstract

The silyl derivatives 3a–c were treated with ethoxymethyl chloride (4a) or (2-acetoxyethoxy)methyl bromide (4b) to afford 5a–c and 6a–c, respectively; 7a–c were prepared by treating 6a–c with MeONa; treatment of 5a–c or 6a–c with tris(1H-1,2,4-triazole-1-yl)phosphine oxide and subsequent reaction of 8a–c and 9a–c with ammonia in dioxane to give 10a–c and 11a–c; ammonolysis of 11a–c yielded the hydroxyalkyl derivatives 12a–c.

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