Facile Synthesis of 5-(Substituted vinyl)-uracil Derivatives through Knoevenagel and Stobbe type Condensations of 5-Formyluracils

Abstract

5-Formyl-1,3-dimethyl/1,3,6-trimethyl uracils (1) react with malononitrile, ethyl cyanoacetate, phenyl acetonitrile/acetyl acetone in Knoevenagel and with diethyl/dimethyl malonates in Stobbe modes to provide respective 5-(ethoxy/methoxy carbonyl)vinyluracils.

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