Studies on Regioselective Addition of Alkyl(phosphine)copper Complexes to Epoxides

Abstract

An alkyl(phosphine)copper complex performed alkylative ring opening of a monosubstituted epoxide, but not that of a 1,2-disubstituted or trisubstituted epoxide, and, upon reaction with this complex, a diepoxy compound comprising terminal and internal epoxy functionalities in a single molecule formed a product based on preferential attack at the terminal functionality.

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