Reaction between Alkyl Isocyanides and Dimethyl Acetylenedicarboxylate in Presence of N,N′-Dimethylbarbituric Acid. A Convenient Route to Highly Functionalized 4H-Pyrano[3,2-d]pyrimidine Derivatives

Abstract

The highly reactive 1:1 intermediate produced in the reaction between alkyl isocyanides and dimethyl acetylenedicarboxylate is trapped by N,N′-dimethylbarbituric acid to yield 4H-pyrano[3,2-d]pyrimidine derivatives in fairly high yields.

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