Stereoselective Synthesis of Dialkyl 2-(3-Methoxy-1-oxoinden-2-yl)-3-(dimethylphosphonato)-butanedioates

Abstract

Protonation of the reactive intermediate produced in the reaction between trimethyl phosphite and dialkyl acetylenedicarboxylates by indane-1,3-dione leads to vinyltrimethoxyphosphonium cation, which undergoes addition reaction with the enolate anion of the CH-acid to produce the title compounds in fairly high yields.

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