A Simple Aid to the Assignment of 13C NMR Spectra, based on the Visual Differences caused by Deuteriation

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John E. O'Brien, T. Brian H. McMurry and Conor N. O'Callaghan


Abstract

Selective deuteriation of complex polyheterocyclic compounds effects changes in the intensities of the 13C NMR signals which can be used to solve assignment problems.


References

  1. R. E. Echols and G. C. Levy, J. Org. Chem., 1974, 39, 1321 CrossRef CAS.
  2. M. J. Shapiro, M. X. Kolpak and T. Lemka, J. Org. Chem., 1984, 49, 187 CrossRef CAS.
  3. For a review, see C. F. Jameson, in Isotopes in Physical and Biochemical Sciences, ed. E. Buncel and J. R. James, Elsevier, Amsterdam, vol. 2, pp. 1–55 Search PubMed.
  4. P. E. Hansen, S. N. Ibsen, T. Kristensen and S. Bolvig, Magn. Reson. Chem., 1994, 32, 399 CAS and refs. therein.
  5. R. A. Bell, C. L. Chen and B. G. Sayer, J. Chem. Soc., Chem. Commun., 1972, 67 RSC.
  6. J. Reuben, J. Am. Chem. Soc., 1987, 109, 316 CrossRef CAS.
  7. C. N. O'Callaghan, T. B. H. McMurry and J. E. O'Brien, J. Chem. Soc., Perkin Trans. 1, 1995, 417 RSC.
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