DOI: 10.1039/A800584B
(Paper)
Reference Section for: J. Chem. Res. (S), 1998, 283-283
Enantiospecific Synthesis of Analogues of the Diketide Intermediate of the Erythromycin Polyketide Synthase (PKS)
(Note: The full text of this document is currently only available in the PDF Version )
Rebecca C. Harris, Annabel L. Cutter, Kira J. Weissman, Ulf Hanefeld, Ma′ire C. Timoney and James Staunton
Abstract
The four stereoisomers of 3-hydroxy-2-methylpentanoic acid (1a–d) and the structurally modified acids 1e–j have been synthesised enantiospecifically and converted into p-nitrophenyl ester and thioester derivatives; as the activated derivatives; they are available for investigations into the substrate selectivity of polyketide synthase (PKS) domains.
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